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The hydroxyurea 1,000 mg tablets (Siklos) are scored so that they can easily be split into halves or quarters to provide smaller doses. Do not break the hydroxyurea 100 mg …Common Side Effects of Hydroxyurea. Tell your doctor if any of the following symptoms become severe or don’t go away: Nausea, vomiting, or diarrheaDevelopmental toxicity – Hydroxyurea information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums …Hydroxyurea information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.Hydroxyurea can cause harm to the unborn baby and therefore, should not be used during pregnancy. Although there are no adequate and well-controlled studies in pregnant women, in animals studies hydroxyurea was found to cause birth defects. Hydroxyurea is secreted in human milk.Hydroxyurea use by either parent may cause birth defects. After the last dose of hydroxyurea, a man must use birth control for much longer than a woman. For women: Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your treatment ends.Hydroxyurea is mutagenic in vitro to bacteria, fungi, protozoa, and mammalian cells. Hydroxyurea is clastogenic in vitro (hamster cells, human lymphoblasts) and in vivo (SCE assay in rodents, mouse micronucleus assay). Hydroxyurea causes the transformation of rodent embryo cells to a tumorigenic phenotype.Hydroxyurea is a pill, taken by mouth. Take Hydroxyurea exactly as prescribed. Hydroxyurea may be dissolved in water. The amount of Hydroxyurea that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated.Hydroxyurea official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.